Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, and Transforming Growth Factor Beta 1 Levels in Escherichia coli-Infected Rats with Acute Pyelonephritis

Objective: To investigate the expression of matrix metalloproteinase-2 (MMP-2), metalloproteinase-9 (MMP-9), and transforming growth factor beta 1 (TGF 1) in kidney tissue rats with pyelonephritis their relationship by establishing a rat model acute pyelonephritis. Methods: 80 male Wistar were randomly divided into control group an experimental group, 40 each. The injected saline those 10 ?g/mL Escherichia coli (E. coli) (1:100); solutions for both groups administered every 3 days 7 days. expressions MMP-2, MMP-9 TGF tissues each observed. Results: 1in was significantly higher than (P < 0.01); mRNA content that 0.05); renal increased compared to began express early stage until complete formation pelvic edema. difference between statistically significant 0.01). Conclusion: are important factors regulating tubular epithelial cell injury inflammatory response.